Select Publications

Niemeyer BF; Zhao P; Tuder RM; Benam KH. “Advanced Microengineered Lung Models for Translational Drug Discovery”, SLAS Discovery 2018; Feb 15. doi: 10.1177/2472555218760217. [Epub ahead of print].

Benam KH. “Disrupting Experimental Strategies for Inhalation Toxicology: The Emergence of Microengineered Breathing-Smoking Human Lung-on-a-Chip”, Applied In Vitro Toxicology 2018; Feb 8. doi: 10.1089/aivt.2017.0030. [Epub ahead of print].

Benam KH*; Königshoff M; Eickelberg O. “Breaking the In Vitro Barrier in Respiratory Medicine: Engineered Microphysiological Systems for COPD and Beyond”, American Journal of Respiratory and Critical Care Medicine 2017; Dec 20. doi: 10.1164/rccm.201709-1795PP. [Epub ahead of print]. *: corresponding author.

Benam KH; Mazur M; Ferrante TC; Choe Y; Novak R; Ingber DE. “Human Lung Small Airway-on-a-Chip Protocol”, Methods in Molecular Biology 2017; 1612:345-365.  doi: 10.1007/978-1-4939-7021-6_25.

Cole SL; Kok WL; Dunning J; Benam KH; Benlahrech A; Repappi E; Drumright L; Powell TJ; Bennett M; MOSAIC Investigators; Dong T; McCauley J; Liew EFY; Taylor S; Cerundolo V; Openshaw P; McMichael AJ; Ho LP. “Critical role for M1-M2 monocyte-macrophage imbalance in life-threatening influenza virus infection”, JCI Insight 2017; 2(7):e91868. doi: 10.1172/jci.insight.91868.

Benam KH; Novak R; Nawroth J; Hirano-Kobayashi M; Ferrante TC; Choe Y; Prantil-Baun R; Weaver JC; Bahinski A; Parker KK; Ingber DE. “Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip”, Cell Systems 2016; 3(5):456-466.e4. doi: 10.1016/j.cels.2016.10.003.

  • Selected third on The Aspen Institute’s Five Best Ideas of the Day (Oct 31st 2016).
  • Featured in a ‘Preview’ by Tejavibulya N & Sia S.K. “Personalized Disease Models on a Chip”, Cell Systems 2016; 3(5):416-418. doi: 10.1016/j.cels.2016.11.002.

Benam KH; Ingber DE. “Commendation for Exposing Key Advantage of Organ Chip Approach”, Cell Systems 2016; 3(5):411. doi 10.1016/j.cels.2016.11.009. Published as ‘Featured Frontmatter.

Benam KH; Villenave R; Lucchesi C; Varone A; Hubeau C; Lee HH; Salmon M; Alves S; Ferrante TC; Weaver J; Bahinski A; Hamilton G; Ingber DE. “Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro”, Nature Methods 2016; 13(2):151-157. doi: 10.1038/nmeth.3697.

  • Featured in ‘Research Highlight, Respiratory Diseases’, Nature Reviews Drug Discovery 2016; 15(2):86. doi: 10.1038/nrd.2016.7. and Recommended by Faculty of 1000 (F1000 Prime).

Benam KH; Dauth S; Hassell B; Herland A; Jain A; Jang KJ; Karalis K; Kim HJ; MacQuee L; Mahmoodian R; Musah S; Torisawa Y; van der Meer AD; Villenave R; Yadid M; Parker KK; Ingber DE. “Engineered In Vitro Disease Models”, Annual Review of Pathology: Mechanisms of Disease 2015; 10:195-262. doi: 10.1146/annurev-pathol-012414-040418.

Cole SL; Benam KH; McMichael AJ; Ho LP. “Involvement of the 4-1BB/4-1BBL Pathway in Control of Monocyte Numbers by Invariant NKT Cells”, Journal of Immunology 2014; 192(8):3898-3907. doi: 10.4049/jimmunol.1302385.

Kok WL; Denney L; Benam KH; Cole S; Clelland C; McMichael AJ; Ho LP. “Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection”, Journal of Leukocyte Biology 2012; 91(3):357-368. doi: 10.1189/jlb.0411184.

  • Published as ‘Pivotal Advance’ and featured in a companion Editorial: Exley MA. “NKT get the flu: NKT cells as (mostly) good guys in influenza; monocytic cells as double agents”, Journal of Leukocyte Biology 2012; 91(3):349-52. doi: 10.1189/jlb.0911468.

Benam KH; Kok WL; McMichael AJ; Ho LP. “Alternative spliced CD1D transcripts in human bronchial epithelial cells”, PLoS ONE 2011; 6(8):e22726. doi: 10.1371/journal.pone.0022726.